.. وتسأل المريض عن اى مشاكل نفسيه او عصبيه او حتى هو مريض diabetes يقولك لأ ..
طب يا ترى هو مكتوب ليه ?
هو مكتوب هنا علشان المريض بيعانى من زغوطه hiccups
مستمرة وعنيفه ومش بتروح مع الادوية التقليديه ..
وده off lable use لل gabapentin
● طب ايه ال mechanism ..
The mechanism by which gabapentin decreases hiccup is not well understood. It may selectively diminish calcium influx by inhibiting voltage-operated calcium channels in a subset of excitatory and inhibitory presynaptic terminals, thereby attenuating synaptic transmission
■ طب ممكن يستخدم لوحده ولا لازم حاجه معاه
monotherapy or as an adjunct to other agents [eg, baclofen, cisapride, omeprazole, haloperidol, metoclopramide]) may be of benefit in the treatment of persistent or intractable hiccups
● dose
Patients with severe chronic hiccups were treated with gabapentin (300 mg t.i.d.). Doses of gabapentin were titrated based on the response to treatment.
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